TY - CHAP M1 - Book, Section TI - Hepatic Principles A1 - Delaney, Kathleen A. A1 - Furmaga, Jakub A2 - Nelson, Lewis S. A2 - Howland, Mary Ann A2 - Lewin, Neal A. A2 - Smith, Silas W. A2 - Goldfrank, Lewis R. A2 - Hoffman, Robert S. PY - 2019 T2 - Goldfrank's Toxicologic Emergencies, 11e AB - The liver plays an essential role in metabolic homeostasis. Hepatic functions include the synthesis, storage, and breakdown of glycogen. In addition, the liver is important in the metabolism of lipids; the synthesis of albumin, clotting factors, and other important proteins; the synthesis of the bile acids necessary for absorption of lipids and lipid-soluble vitamins; and the metabolism of cholesterol. Hepatocytes facilitate the excretion of metals, most importantly iron, copper, zinc, manganese, mercury, and aluminum, as well as the detoxification of products of metabolism, such as bilirubin and ammonia.27,59 Generalized disruption of these important functions results in manifestations of liver failure: hyperbilirubinemia, coagulopathy, hypoalbuminemia, hyperammonemia, and hypoglycemia. Disturbances of more specific functions result in accumulation of lipids, metals, and bilirubin, and the development of lipid-soluble vitamin deficiencies.125 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1163008638 ER -