TY - CHAP M1 - Book, Section TI - Nonsteroidal Antiinflammatory Drugs A1 - Holubek, William J. A2 - Nelson, Lewis S. A2 - Howland, Mary Ann A2 - Lewin, Neal A. A2 - Smith, Silas W. A2 - Goldfrank, Lewis R. A2 - Hoffman, Robert S. PY - 2019 T2 - Goldfrank's Toxicologic Emergencies, 11e AB - In the 1950s, the only treatment for rheumatoid arthritis included high-dose aspirin and gold therapy (chrysotherapy). While searching for new compounds that were chemically nonsteroidal and had antiinflammatory properties, Dr. Stewart Adams filed a patent for “Antiinflammatory Agents” in 1961. One of the compounds in this list was 2-(4-isobutylphenyl) propionic acid, which today we call ibuprofen. This discovery created a new class of drugs designated as nonsteroidal antiinflammatory drugs (NSAIDs).36 Ibuprofen was initially marketed in the United Kingdom in 1969 and was introduced to the US market in 1974. Ibuprofen became available without a prescription in the United States in 1984. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1163010252 ER -