TY - CHAP M1 - Book, Section TI - Sleep–Wake Disorders A1 - Dopp, John M. A1 - Phillips, Bradley G. A2 - DiPiro, Joseph T. A2 - Talbert, Robert L. A2 - Yee, Gary C. A2 - Matzke, Gary R. A2 - Wells, Barbara G. A2 - Posey, L. Michael PY - 2017 T2 - Pharmacotherapy: A Pathophysiologic Approach, 10e AB - Content UpdateSeptember 16, 2019Newly Approved Medication for Narcolepsy with or without Cataplexy: The U.S. FDA approved a medication with novel mechanism of action for narcolepsy treatment. Pitolisant (Wakix), the first selective histamine 3 (H3) receptor inverse agonist, was approved in 2019 for narcolepsy.The H3 receptor inverse agonist was approved for treating excessive daytime sleepiness (EDS) in narcolepsy in adults because of its hypothesized role in increasing wake-promoting histamine. While other treatments for EDS are available, this is the first treatment with the mechanism of action involving histamine. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1167752898 ER -