TY - CHAP M1 - Book, Section TI - Agents Used in Dyslipidemia A1 - Malloy, Mary J. A1 - Kane, John P. A2 - Katzung, Bertram G. A2 - Vanderah, Todd W. PY - 2021 T2 - Basic & Clinical Pharmacology, 15e AB - CASE STUDYA 36-year-old man has an LDL-cholesterol of 190 mg/dL, normal triglycerides and HDL. His lipoprotein (a) is four times normal. His coronary calcium score was appropriate for a man of 60 years. He has no symptoms of coronary or peripheral vascular disease. Physical exam was normal except for a systolic aortic valve murmur. His mother had a myocardial infarction at age 51 and had no known risk factors other than an elevated cholesterol. He developed muscle symptoms with each of 3 statins (atorvastatin, rosuvastatin, and simvastatin) but levels of creatine kinase remained normal. On genetic analysis he was heterozygous for the SLCO1B1 mutation associated with statin myopathy, and for a loss of function mutation in the gene for the LDL receptor. His LDL-C goal is in the 40 to 50-mg/dL range because of his two lipoprotein risk factors, his coronary artery calcification, and his mother’s history of premature coronary artery disease. He has no other risk factors and his diet and exercise habits are excellent. How would you manage this patient? SN - PB - McGraw-Hill CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1176467148 ER -