TY - CHAP M1 - Book, Section TI - Hypothalamic & Pituitary Hormones A1 - Long, Roger K. A1 - Cakmak, Hakan A2 - Katzung, Bertram G. A2 - Vanderah, Todd W. PY - 2021 T2 - Basic & Clinical Pharmacology, 15e AB - CASE STUDYA 7-year-old boy (height 113 cm, 5th percentile; weight 23 kg, approximately 50th percentile) presents with short stature. Review of growth chart demonstrates normal birth weight and birth length and growth velocity until a markedly decreased growth velocity over the past 2 years, and decrease from 50th height percentile. Review of history reveals headaches, increased urination, and orthostasis with febrile illnesses. Physical examination demonstrates short stature, mild generalized obesity, visual field defect, and normal prepubertal external male genitalia. The patient is diagnosed with a hypothalamic tumor. After completion of treatment protocol including resection and radiation, laboratory evaluations demonstrate growth hormone (GH) deficiency and a delayed bone age of 18 months. The patient is treated with recombinant human GH at a dose of 40 mcg/kg per day subcutaneously. After 1 year of treatment, his height velocity has increased from 5 cm/y to 11 cm/y. How does GH stimulate growth in children? What other hormone deficiencies are suggested by the patient’s history and physical examination? What other hormone replacements is this patient likely to require? SN - PB - McGraw-Hill CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1176467549 ER -