TY - CHAP M1 - Book, Section TI - Dyslipidemia A1 - Phan, Ha A2 - Sutton, S. Scott PY - 2020 T2 - McGraw Hill’s NAPLEX® Review Guide, 4e AB - Dyslipidemia is defined as elevated total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), or low high-density lipoprotein cholesterol (HDL-C). LDL-C incites the atherosclerotic inflammatory response promoting unstable lesions concentrated with lipid-laden macrophages. The degree of LDL elevation is proportionally linked with risk of developing atherosclerotic cardiovascular disease (ASCVD; 1 mg/dL:1% change). Elevated TG has indirect atherosclerotic effects from procoagulant properties and an adverse impact on endothelial function. In contrast, HDL-C is an inverse predictor for ASCVD risk (1 mg/dL:2% change) due to reverse cholesterol transport (delivering cholesterol from the cell wall to the liver for disposal). Additionally, HDL-C inhibits LDL-C oxidation and platelet aggregation and activation. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1179733043 ER -