TY  - CHAP
M1  - Book, Section
TI  - Drug Distribution and Protein Binding
A1  - Svensson, Craig K.
A2  - Ducharme, Murray P.
A2  - Shargel, Leon
PY  - 2022
T2  - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e
AB  - Explain  the  importance  of  drug  distribution  in  determining  drug  effect.Identify  barriers  to  the  distribution  of  drugs  into  tissues.Describe  the  dynamic  of  drug  binding  to  constituents  in  blood  and  the  impact  on  drug  distribution  in  the  body.Provide  a  concise  statement  of  the  free  drug  hypothesis.Describe  the  effects  of  membrane  transporters  on  drug  distribution  into  select  tissues,  such  as  the  brain.Differentiate  between  the  various  methods  to  quantify  the  distribution  of  drugs  in  the  body.Predict  the  effects  of  changes  in  protein  binding  on  drug  distribution.Describe  the  factors  that  alter  the  protein  binding  of  drugs  to  albumin  and  α1-acid  glycoprotein.Describe  the  primary  methods  to  determine  plasma  and  serum  protein  binding  of  drugs.Determine  drug  binding  constants  from  in  vitro  data.Predict  the  probable  clinical  impact  of  protein  binding  displacement  interactions.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1188766033
ER  -