TY - CHAP M1 - Book, Section TI - Pharmacokinetic Calculations for Drug Elimination and Clearance A1 - Ducharme, Murray P. A1 - Wu, Fang A1 - Zhao, Liang A2 - Ducharme, Murray P. A2 - Shargel, Leon PY - 2022 T2 - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e AB - Discuss the clinical role of clearance as a PK parameter.Calculate clearance using different methods including the noncompartmental, compartmental, and “physiological” approaches.Define clearance and its relationship to a corresponding half-life and a volume of distribution.Differentiate between total, hepatic, and renal clearances.Describe the processes for renal drug excretion and explain which renal excretion process predominates in the kidney for a specific drug given its renal clearance.Describe the renal clearance model based on renal blood flow, glomerular filtration, and drug reabsorption.Be able to calculate if a change in hepatic or renal clearance will have a significant effect or not.Describe hepatic drug clearance in terms of blood flow and extraction using the “physiologic” well-stirred model.Predict the impact of a drug−drug interaction on protein binding or intrinsic clearance on the liver and total drug clearances, unbound exposure, and oral bioavailability for low and highly extracted drugs using the “physiologic” well-stirred model. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1188768847 ER -