TY - CHAP M1 - Book, Section TI - Pharmacokinetics of Drug Absorption A1 - Yue, Corinne Seng A1 - Al-Numani, Dina A2 - Ducharme, Murray P. A2 - Shargel, Leon PY - 2022 T2 - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e AB - Define oral drug absorption and its relevance.Describe different absorption rate processes (eg, first- and zero-order).Calculate the pharmacokinetic parameters of an orally administered drug that is described by a one-compartment model.Calculate the absorption rate constant for an orally administered drug that is described by a two-compartment pharmacokinetic model.Contrast current methods for characterizing absorption against historical methods.Describe flip-flop kinetics for oral extended-release drug products.Discuss the clinical implication of absorption half-life.Discuss how ka and kel influence Cmax, tmax, and AUC.Discuss how changes in these parameters affect drug safety in a clinical situation. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1188769114 ER -