TY - CHAP M1 - Book, Section TI - Multiple-Dosage Regimens A1 - Siwale, Rodney C. A1 - Sani, Shabnam N. A2 - Ducharme, Murray P. A2 - Shargel, Leon PY - 2022 T2 - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e AB - Define the index for measuring drug accumulation.Define drug accumulation and drug accumulation t1/2.Explain the principle of superposition and its assumptions in multiple-dose regimens.Calculate the steady-state Cmax and Cmin after multiple IV bolus dosing of drugs.Calculate k and VD of aminoglycosides in multiple-dose regimens.Adjust the steady-state Cmax and Cmin in the event the last dose is given too early, too late, or totally missed following multiple IV dosing. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1196350293 ER -