TY  - CHAP
M1  - Book, Section
TI  - Chapter 11. Epidemiologic Studies of Genetics
A1  - Greenberg, Raymond S.
A1  - Daniels, Stephen R.
A1  - Flanders, W. Dana
A1  - Eley, John William
A1  - Boring, John R.
PY  - 2005
T2  - Medical Epidemiology, 4e
AB  - Familial  aggregation  of  a  disease  is  suggested  when  the  recurrence  risk  among  relatives  of  affected  persons  exceeds  that  among  relatives  of  unaffected  persons.  In  studies  of  twins,  greater  concordance  for  disease  among  monozygotic  twins  as  compared  with  dizygotic  twins  suggests  genetically  determined  susceptibility.  If  subjects  with  a  high  degree  of  inbreeding  have  an  elevated  risk  of  disease,  an  autosomal  recessive  pattern  of  inheritance  may  be  suggested.  Co-segregation  refers  to  the  tendency  of  alleles  that  are  situated  closely  together  on  the  chromosomes  to  be  inherited  together.  Linkage  of  a  marker  gene  (with  a  known  location  in  the  genome)  and  a  disease  susceptibility  gene  can  suggest  the  particular  chromosome  involved  and  where  on  the  chromosome  the  susceptibility  gene  is  likely  to  be  located.  Segregation  analysis  of  pedigrees  is  a  complex  statistical  technique  used  to  determine  whether  a  disease  has,  at  least  in  part,  a  genetic  origin,  and  if  so,  the  likely  pattern  of  inheritance.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/16
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=546260
ER  -