TY - CHAP M1 - Book, Section TI - Chapter 2. Clinical Pharmacokinetic Equations and Calculations A1 - Bauer, Larry A. A2 - Bauer, Larry A. PY - 2008 T2 - Applied Clinical Pharmacokinetics, 2e AB - Clinical pharmacokinetic dosage calculations are conducted using the easiest possible equations and methods. This is because there are usually only a few (sometimes as little as 1–2) drug serum concentrations on which to base the calculations. Drug serum concentrations are expensive (typically $25–75 each), and obtaining them can cause minor discomfort and trauma to the patient. This situation is much different than that found in pharmacokinetic research studies where there may be 10–15 drug serum concentrations used to calculate pharmacokinetic parameters, and more complex equations can be used to describe the pharmacokinetics of the drug. Since the goal of therapeutic drug monitoring in patients is to individualize the drug dose and serum concentrations in order to produce the desired pharmacological effect and avoid adverse effects, it may not be possible, or even necessary, to compute pharmacokinetic parameters for every patient or clinical situation. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=3518598 ER -