TY  - CHAP
M1  - Book, Section
TI  - Chapter 13. Phenobarbital/Primidone
A1  - Bauer, Larry A.
A2  - Bauer, Larry A.
PY  - 2008
T2  - Applied Clinical Pharmacokinetics, 2e
AB  - Phenobarbital  is  a  barbiturate  and  primidone  is  a  deoxybarbiturate  that  are  effective  in  the  treatment  of  generalized  tonic-clonic  and  partial  seizures  (Table  13-1).1,2  Phenobarbital  is  available  as  a  separate  agent,  but  is  also  an  active  metabolite  produced  via  hepatic  metabolism  during  primidone  treatment.  Because  of  this,  and  because  they  share  a  similar  antiseizure  spectrum,  these  two  drugs  are  considered  together  in  this  chapter.  The  probable  mechanism  of  action  for  phenobarbital  is  elevation  of  seizure  threshold  by  interacting  with  γ-aminobutyric  acidA  (GABAA)  postsynaptic  receptors  which  potentiates  synaptic  inhibition.3,4  While  the  exact  mechanism  of  action  is  not  known  for  the  antiepileptic  effect  of  primidone,  a  portion  of  its  antiseizure  activity  is  produced  by  the  active  metabolites  phenobarbital  and  phenylethylmalonamide  (PEMA).3,4  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=3517648
ER  -