TY - CHAP M1 - Book, Section TI - Chapter 25. Sepsis and Septic Shock A1 - Miller, April D. A1 - Sutton, S. Scott A2 - Sutton, S. Scott PY - 2011 T2 - McGraw-Hill's NAPLEX® Review Guide AB - Sepsis is the leading cause of morbidity and mortality for critically ill patients, and the tenth leading cause of death overall.1 There are 660,000 to 750,000 cases of sepsis annually. Care of septic patients costs $17 billion in the United States per year ($22,000-$50,000 per patient).2 Sepsis is a continuum of physiologic stages characterized by infection, systemic inflammation, and hypoperfusion with widespread tissue injury. The American College of Chest Physicians and the Society of Critical Care Medicine developed definitions to utilize for sepsis (Table 25-1).3 Risk factors for sepsis include extremes of age, cancer, immunodeficiency, chronic organ failure, genetic factors (male, and non-white ethnic origin in North America), bacteremic patients, and polymorphisms in genes that regulate immunity. Pulmonary, gastrointestinal, genitourinary, and bloodstream infections account for the majority of sepsis cases.4 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=7252013 ER -