TY  - CHAP
M1  - Book, Section
TI  - Chapter 7. Pharmacokinetics of Oral Absorption
A1  - Shargel, Leon
A1  - Wu-Pong, Susanna
A1  - Yu, Andrew B.C.
PY  - 2012
T2  - Applied Biopharmaceutics & Pharmacokinetics, 6e
AB  - The  pharmacokinetics  of  drugs  following  intravenous  drug  administration  are  simpler  to  model  compared  to  extravascular  delivery  (see  Chapters  1–6).  Extravascular  delivery  routes,  particularly  oral  dosing,  are  important  and  popular  means  of  drug  administration.  Unlike  intravenous  administration,  in  which  the  drug  is  injected  directly  into  the  plasma,  pharmacokinetic  models  after  extravascular  drug  administration  must  consider  systemic  drug  absorption  from  the  site  of  administration,  for  example,  the  lung,  the  gut,  etc,  into  the  plasma.  Extravascular  drug  delivery  is  further  complicated  by  variables  at  the  absorption  site,  including  possible  drug  degradation,  metabolism,  and  significant  inter-  and  intrapatient  differences  in  the  rate  and  extent  of  absorption.  Absorption  and  metabolic  variables  are  characterized  using  pharmacokinetic  methods.  The  variability  in  systemic  drug  absorption  can  be  minimized  to  some  extent  by  proper  biopharmaceutical  design  of  the  dosage  form  to  provide  predictable  and  reliable  drug  therapy  (see  Chapters  14–16).  The  major  advantage  of  intravenous  administration  compared  to  extravascular  drug  absorption  is  that  the  rate  and  extent  of  systemic  drug  input  are  carefully  controlled.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=56602497
ER  -