TY - CHAP M1 - Book, Section TI - Chapter 7. Pharmacokinetics of Oral Absorption A1 - Shargel, Leon A1 - Wu-Pong, Susanna A1 - Yu, Andrew B.C. PY - 2012 T2 - Applied Biopharmaceutics & Pharmacokinetics, 6e AB - The pharmacokinetics of drugs following intravenous drug administration are simpler to model compared to extravascular delivery (see Chapters 1–6). Extravascular delivery routes, particularly oral dosing, are important and popular means of drug administration. Unlike intravenous administration, in which the drug is injected directly into the plasma, pharmacokinetic models after extravascular drug administration must consider systemic drug absorption from the site of administration, for example, the lung, the gut, etc, into the plasma. Extravascular drug delivery is further complicated by variables at the absorption site, including possible drug degradation, metabolism, and significant inter- and intrapatient differences in the rate and extent of absorption. Absorption and metabolic variables are characterized using pharmacokinetic methods. The variability in systemic drug absorption can be minimized to some extent by proper biopharmaceutical design of the dosage form to provide predictable and reliable drug therapy (see Chapters 14–16). The major advantage of intravenous administration compared to extravascular drug absorption is that the rate and extent of systemic drug input are carefully controlled. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/11/14 UR - accesspharmacy.mhmedical.com/content.aspx?aid=56602497 ER -