TY  - CHAP
M1  - Book, Section
TI  - Chapter 9. Nonlinear Pharmacokinetics
A1  - Shargel, Leon
A1  - Wu-Pong, Susanna
A1  - Yu, Andrew B.C.
PY  - 2012
T2  - Applied Biopharmaceutics & Pharmacokinetics, 6e
AB  - Previous  chapters  discussed  linear  pharmacokinetic  models  using  simple  first-order  kinetics  to  describe  the  course  of  drug  disposition  and  action.  These  linear  models  assumed  that  the  pharmacokinetic  parameters  for  a  drug  would  not  change  when  different  doses  or  multiple  doses  of  a  drug  were  given.  With  some  drugs,  increased  doses  or  chronic  medication  can  cause  deviations  from  the  linear  pharmacokinetic  profile  previously  observed  with  single  low  doses  of  the  same  drug.  This  nonlinear  pharmacokinetic  behavior  is  also  termed  dose-dependentpharmacokinetics.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=56602910
ER  -