TY  - CHAP
M1  - Book, Section
TI  - Chapter 14. Biopharmaceutic Considerations in Drug Product Design and In Vitro Drug Product Performance
A1  - Shargel, Leon
A1  - Wu-Pong, Susanna
A1  - Yu, Andrew B.C.
PY  - 2012
T2  - Applied Biopharmaceutics & Pharmacokinetics, 6e
AB  - Biopharmaceutics  is  the  study  of  the  physicochemical  properties  of  the  drug  and  the  drug  product,  in  vitro,  on  the  bioavailability  of  the  drug,  in  vivo,  to  produce  a  desired  therapeutic  effect.  Biopharmaceutics  links  the  physical  and  chemical  properties  of  the  drug  and  the  drug  product  to  their  performance,  in  vivo.  A  primary  concern  in  biopharmaceutics  is  the  bioavailability  of  drugs.  Bioavailability  refers  to  the  measurement  of  the  rate  and  extent  of  active  drug  that  becomes  available  at  the  site  of  action.  Oral  drug  absorption  involves  at  least  three  distinct  steps:  drug  release  and  dissolution  from  the  drug  product,  permeation  of  the  drug  across  the  gastrointestinal  (GI)  linings,  and  drug  disposition  during  GI  transit.  Additional  drug  disposition  may  occur  in  the  body.  Because  the  systemic  blood  circulation  delivers  therapeutically  active  drug  to  the  tissues  and  to  the  site  of  action  of  the  drug,  changes  in  bioavailability  affect  changes  in  the  pharmacodynamics  and  toxicity  of  a  drug.  The  aim  of  biopharmaceutics  is  to  adjust  the  delivery  of  drug  from  the  drug  product  in  such  a  manner  as  to  provide  optimal  therapeutic  activity  and  safety  for  the  patient.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=56604846
ER  -