TY  - CHAP
M1  - Book, Section
TI  - Chapter 19. Relationship between Pharmacokinetics and Pharmacodynamics
A1  - Shargel, Leon
A1  - Wu-Pong, Susanna
A1  - Yu, Andrew B.C.
PY  - 2012
T2  - Applied Biopharmaceutics & Pharmacokinetics, 6e
AB  - In  the  previous  chapters,  pharmacokinetics  was  used  to  develop  dosing  regimens  for  achieving  therapeutic  drug  concentrations  for  optimal  safety  and  efficacy.  The  interaction  of  a  drug  molecule  with  a  receptor  causes  the  initiation  of  a  sequence  of  molecular  events,  resulting  in  a  pharmacodynamic  or  pharmacologic  response.  The  term  pharmacodynamics  refers  to  the  relationship  between  drug  concentrations  at  the  site  of  action  (receptor)  and  pharmacologic  response.  Pharmacodynamics  includes  the  biochemical  and  physiologic  effects  that  result  from  the  interaction  of  the  drug  with  the  receptor.  Early  pharmacologic  research  demonstrates  that  the  pharmacodynamic  response  produced  by  the  drug  depends  on  the  chemical  structure  of  the  drug  molecule  and  the  affinity  of  the  drug  at  the  receptor  site.  The  drug  affinity  for  the  receptor  site  and  the  resultant  pharmacodynamic  response  is  referred  to  as  the  intrinsic  activity  of  the  drug.  Drug  receptors  interact  only  with  drugs  of  specific  chemical  structure,  and  the  receptors  are  classified  according  to  the  type  of  pharmacodynamic  response  induced.  Drugs  may  be  considered  a  full  agonist,  partial  agonist,  or  antagonist,  depending  upon  the  type  of  drug  interaction  with  the  receptor  and  the  resulting  pharmacodynamic  response  (see  discussion  below).  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=56606660
ER  -