TY  - CHAP
M1  - Book, Section
TI  - Chapter 20. Application of Pharmacokinetics to Clinical Situations
A1  - Shargel, Leon
A1  - Wu-Pong, Susanna
A1  - Yu, Andrew B.C.
PY  - 2012
T2  - Applied Biopharmaceutics & Pharmacokinetics, 6e
AB  - The  success  of  drug  therapy  is  highly  dependent  on  the  choice  of  the  drug,  the  drug  product,  and  the  design  of  the  dosage  regimen.  The  choice  of  the  drug  is  generally  made  by  the  physician  after  careful  patient  diagnosis  and  physical  assessment.  The  choice  of  the  drug  product  (eg,  immediate  release  vs  modified  release)  and  dosage  regimen  are  based  on  the  patient's  individual  characteristics  and  known  pharmacokinetics  of  the  drug  as  discussed  in  earlier  chapters.  Ideally,  the  dosage  regimen  is  designed  to  achieve  a  desired  drug  concentration  at  a  receptor  site  to  produce  an  optimal  therapeutic  response  with  minimum  adverse  effects.  Individual  variation  in  pharmacokinetics  and  pharmacodynamics  makes  the  design  of  dosage  regimens  difficult.  Therefore,  the  application  of  pharmacokinetics  to  dosage  regimen  design  must  be  coordinated  with  proper  clinical  evaluation  of  the  patient.  For  certain  critical-dose  drugs,  monitoring  both  the  patient  and  drug  regimen  is  important  for  proper  efficacy.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/16
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=56607021
ER  -