TY - CHAP M1 - Book, Section TI - Chapter 26. Local Anesthetics A1 - Trevor, Anthony J. A1 - Katzung, Bertram G. A1 - Kruidering-Hall, Marieke M. A1 - Masters, Susan B. PY - 2013 T2 - Katzung & Trevor's Pharmacology: Examination & Board Review, 10e AB - Local anesthesia is the condition that results when sensory transmission from a local area of the body to the CNS is blocked. The local anesthetics constitute a group of chemically similar agents (esters and amides) that block the sodium channels of excitable membranes. Because these drugs can be administered by injection in the target area, or by topical application in some cases, the anesthetic effect can be restricted to a localized area (eg, the cornea or an arm). When given intravenously, local anesthetics have effects on other tissues. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=56982042 ER -