TY  - CHAP
M1  - Book, Section
TI  - Antidotes
A1  - Hughes, Darrel W.
A2  - Attridge, Rebecca L.
A2  - Miller, Monica L.
A2  - Moote, Rebecca
A2  - Ryan, Laurajo
PY  - 2013
T2  - Internal Medicine: A Guide to Clinical Therapeutics
AB  - Table  Graphic  Jump  LocationTable  A-1  AntiodotesView  Table||Download  (.pdf)Table  A-1  AntiodotesIndicationAntidoteDosingConsiderationsAvailabilityAcetaminophenOral  N-acetylcysteine  (NAC)Loading  dose:  140mg/kg  diluted  in  juice  or  sodaMaintenance  dose  70mg/kg  Q4h  ×  17  dosesSolution  for  inhalation/oral:  10%,  20%;  10,  30mLAcetaminophenIntravenous  NACLoading  dose:  150mg/kg  in  2mL  D5W  over  1hMaintenance  dose  50mg/kg  in  500  mL  D5W  over  4h;  then  100mg/kg  in  1000mL  of  D5W  over  16h;  dosing  based  on  ideal  body  weight;  for  pediatric  poisonings,  use  smaller  volumes  of  D5W  diluentSolution  for  injection:  20%;  30mLAlcohols  (ethylene  glycol,  methanol)FomepizoleLoading:  15mg/kg;  Maintenance:  10mg/kg  Q12h  ×  4  dosesAdminister  as  IV  infusion  over  30min;  continue  therapy  until  ethylene  glycol  or  methanol  concentrations  500mcg/dL;  hypotension  requiring  crystalloid  boluses  commonPowder  for  reconstitution:  500mg;  2gIsoniazid,  hydrazinePyridoxine5g  IV;  do  not  exceed  0.5g/minDose  gram-per-gram  with  isoniazid  up  to  5g;  repeat  doses  as  need  for  continued  seizure  activity;  consider  benzodiazepine  or  barbiturates  for  seizureSolution  for  injection:  100mg/mL;  1mLLipophilic  cardiotoxic  agentsIntravenous  lipid  emulsionBolus  1.5mL/kg  IV  followed  by  0.25mL/kg/minConsider  repeat  bolus  if  inadequate  response  after  1hSolution  for  injection:  20%;  100,  250,  500,  1000mLMethemoglobinemia  (drug-induced)Methylene  blue1–2mg/kg  IV  over  5minRepeat  dose  if  no  improvement  is  observed  within  1h;  repeat  dose  every  6h  if  methemoglobin  concentrations  are  >30%Solution  for  injection:  10mg/mL;  1,  10mLOpioidNaloxoneAcute  overdose:  0.4–2mg  slow  IV  pushChronic  overdose:  0.04–0.08mgRepeat  doses  Q5min  until  desired  response;  for  chronic  overdose,  consider  starting  at  lower  dose  to  avoid  precipitating  withdrawal;  repeat  dosing  maybe  required  for  re-sedation;  continuous  infusions  of  two  thirds  the  effective  bolus  per  hour  usually  maintains  adequate  respiration  &  airway  protectionSolution  for  injection:  0.4mg/mL;  1,  10mL,  1mg/mL;  2mLOrganophosphate  (muscarinic)Atropine1–3mg  IV  Q3–5minContinue  doubling  dose  &  administer  Q3–5min  as  needed  to  dry  pulmonary  secretions;  large  doses  sometimes  required  (hundreds  of  mg);  atropinization  may  be  required  for  hours  to  days;  monitor  for  atropine  toxicitySolution  for  injection:  0.05mg/mL;  5mL,  ...
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/16
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=57296003
ER  -