RT Book, Section
A1 Colucci, Philippe
A1 Ducharme, Murray P.
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117895704
T1 Applications of Software Packages in Pharmacokinetics
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117895704
RD 2024/04/18
AB The  term  “pharmacokinetics”  (PK)  is  relatively  young  and  was  first  introduced  in  1953  (Wagner  1981).  Although  some  of  the  concepts  associated  with  pharmacokinetics  are  much  older  (eg,  Michaelis–Menten  equation  in  1913,  Hill  equation  in  1908),  the  study  of  pharmacokinetics  and  pharmacodynamics  (PD)  has  only  been  popularized  over  the  last  60  years.  Since  the  early  conceptions  of  compartmental  PK  analysis  in  the  1960s  and  noncompartmental  analysis  in  the  1970s,  the  studies  of  PK  and/or  PD  in  drug  development  have  advanced  rapidly.  These  advancements  are  strongly  correlated  with  the  explosion  of  computers,  especially  personal  computers  (PCs).  Computer  speed  and  storage  capacity  have  doubled  approximately  every  2  years  over  the  last  40  years  (Keyes  2006).  Therefore,  mathematical  computation  time  has  dramatically  shortened  over  the  same  period  of  time.