RT Book, Section
A1 Colucci, Philippe
A1 Ducharme, Murray P.
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117895704
T1 Applications of Software Packages in Pharmacokinetics
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117895704
RD 2022/12/08
AB The term “pharmacokinetics” (PK) is relatively young and was first introduced in 1953 (Wagner 1981). Although some of the concepts associated with pharmacokinetics are much older (eg, Michaelis–Menten equation in 1913, Hill equation in 1908), the study of pharmacokinetics and pharmacodynamics (PD) has only been popularized over the last 60 years. Since the early conceptions of compartmental PK analysis in the 1960s and noncompartmental analysis in the 1970s, the studies of PK and/or PD in drug development have advanced rapidly. These advancements are strongly correlated with the explosion of computers, especially personal computers (PCs). Computer speed and storage capacity have doubled approximately every 2 years over the last 40 years (Keyes 2006). Therefore, mathematical computation time has dramatically shortened over the same period of time.