RT Book, Section
A1 Lee, David S.H.
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117896709
T1 One-Compartment Open Model: Intravenous Bolus Administration
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117896709
RD 2021/11/28
AB Describe a one-compartment model, IV bolus injection.Provide the pharmacokinetic terms that describe a one-compartment model, IV bolus injection, and the underlying assumptions.Explain how drugs follow one-compartment kinetics using drug examples that follow one-compartment kinetics.Calculate pharmacokinetic parameters from drug concentrationâ€“time data using a one-compartment model.Simulate one-compartment plasma drug level graphically using the one-compartment model equation.Calculate the IV bolus dose of a drug using the one-compartment model equation.Relate the relevance of the magnitude of the volume of distribution and clearance of various drugs to underlying processes in the body.Derive model parameters from slope and intercept of the appropriate graphs.