RT Book, Section
A1 Sani, Shabnam N.
A1 Siwale, Rodney C.
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117897047
T1 Multicompartment Models: Intravenous Bolus Administration
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117897047
RD 2021/10/22
AB Define the pharmacokinetic terms used in a two- and three-compartment model.Explain using examples why drugs follow one-compartment, two-compartment, or three-compartment kinetics.Use equations and graph to simulate plasma drug concentration at various time periods after an IV bolus injection of a drug that follows the pharmacokinetics of a two- and three-compartment model drug.Relate the relevance of the magnitude of the volume of distribution and clearance of various drugs to underlying processes in the body.Estimate two-compartment model parameters by using the method of residuals.Calculate clearance and alpha and beta half-lives of a two-compartment model drug.Explain how drug metabolic enzymes, transportors, and binding proteins in the body may modify the distribution and/or elimination phase of a drug after IV bolus.