RT Book, Section A1 Sani, Shabnam N. A1 Siwale, Rodney C. A2 Shargel, Leon A2 Yu, Andrew B.C. SR Print(0) ID 1117897047 T1 Multicompartment Models: Intravenous Bolus Administration T2 Applied Biopharmaceutics & Pharmacokinetics, 7e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071830935 LK accesspharmacy.mhmedical.com/content.aspx?aid=1117897047 RD 2024/03/28 AB Define the pharmacokinetic terms used in a two- and three-compartment model.Explain using examples why drugs follow one-compartment, two-compartment, or three-compartment kinetics.Use equations and graph to simulate plasma drug concentration at various time periods after an IV bolus injection of a drug that follows the pharmacokinetics of a two- and three-compartment model drug.Relate the relevance of the magnitude of the volume of distribution and clearance of various drugs to underlying processes in the body.Estimate two-compartment model parameters by using the method of residuals.Calculate clearance and alpha and beta half-lives of a two-compartment model drug.Explain how drug metabolic enzymes, transportors, and binding proteins in the body may modify the distribution and/or elimination phase of a drug after IV bolus.