RT Book, Section
A1 Ducharme, Murray P.
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117897604
T1 Drug Elimination, Clearance, and Renal Clearance
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117897604
RD 2024/04/19
AB Describe  the  main  routes  of  drug  elimination  from  the  body.Understand  the  importance  of  the  role  of  clearance  as  a  PK  parameter.Define  clearance  and  its  relationship  to  a  corresponding  half-life  and  a  volume  of  distribution.Differentiate  between  clearance  and  renal  clearance.Describe  the  processes  for  renal  drug  excretion  and  explain  which  renal  excretion  process  predominates  in  the  kidney  for  a  specific  drug,  given  its  renal  clearance.Describe  the  renal  clearance  model  based  on  renal  blood  flow,  glomerular  filtration,  and  drug  reabsorption.Describe  organ  drug  clearance  in  terms  of  blood  flow  and  extraction.Calculate  clearance  using  different  methods  including  the  physiological,  noncompartmental,  and  compartmental  approaches.