RT Book, Section
A1 Siwale, Rodney C.
A1 Sani, Shabnam N.
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117898190
T1 Multiple-Dosage Regimens
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117898190
RD 2024/04/18
AB Define  the  index  for  measuring  drug  accumulation.Define  drug  accumulation  and  drug  accumulation  t1/2.Explain  the  principle  of  superposition  and  its  assumptions  in  multiple-dose  regimens.Calculate  the  steady-state  Cmax  and  Cmin  after  multiple  IV  bolus  dosing  of  drugs.Calculate  k  and  VD  of  aminoglycosides  in  multiple-dose  regimens.Adjust  the  steady-state  Cmax  and  Cmin  in  the  event  the  last  dose  is  given  too  early,  too  late,  or  totally  missed  following  multiple  IV  dosing.