RT Book, Section
A1 Yu, Andrew B.C.
A1 Shargel, Leon
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117898518
T1 Nonlinear Pharmacokinetics
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117898518
RD 2024/04/19
AB Describe  the  differences  between  linear  pharmacokinetics  and  nonlinear  pharmacokinetics.Illustrate  nonlinear  pharmaco­kinetics  with  drug  disposition  examples.Discuss  some  potential  risks  in  dosing  drugs  that  follow  nonlinear  kinetics.Explain  how  to  detect  nonlinear  kinetics  using  AUC-versus-doses  plots.Apply  the  appropriate  equation  and  graphical  methods,  to  calculate  the  Vmax  and  KM  parameters  after  multiple  dosing  in  a  patient.Describe  the  use  of  the  Michaelis–Menten  equation  to  simulate  the  elimination  of  a  drug  by  a  saturable  enzymatic  process.Estimate  the  dose  for  a  nonlinear  drug  such  as  phenytoin  in  multiple-dose  regimens.Describe  chronopharmaco­kinetics,  time-dependent  pharmacokinetics,  and  its  influence  on  drug  disposition.Describe  how  transporters  may  cause  uneven  drug  distribution  at  cellular  level;  and  understand  that  capacity-limited  or  concentration-dependent  kinetics  may  occur  at  the  local  level  within  body  organs.