RT Book, Section
A1 Abraham, Thomas
A1 Adams, Michael
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117899508
T1 Pharmacogenetics and Drug Metabolism
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117899508
RD 2024/04/24
AB Define  pharmacogenetics  and  pharmacogenomics.Define  genetic  polymorphism  and  explain  the  difference  between  genotype  and  phenotype.Explain  with  relevant  examples  how  genetic  variability  influences  drug  response,  pharmacokinetics,  and  dosing  regimen  design.Describe  the  relevance  of  CYP  enzymes  and  their  genetic  variability  to  pharmacokinetics  and  dosing.List  the  major  drug  transporters  and  describe  how  their  genetic  variability  can  impact  pharmacokinetics.Discuss  the  main  issues  in  applying  genomic  data  to  patient  care,  for  example,  clinical  interpretation  of  data  from  various  laboratories  and  accuracy  of  record  keeping  of  large  amounts  of  genomic  data.