RT Book, Section A1 Gerk, Phillip M. A1 Yu, Andrew B. C. A1 Shargel, Leon A2 Shargel, Leon A2 Yu, Andrew B.C. SR Print(0) ID 1117899816 T1 Physiologic Factors Related to Drug Absorption T2 Applied Biopharmaceutics & Pharmacokinetics, 7e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071830935 LK accesspharmacy.mhmedical.com/content.aspx?aid=1117899816 RD 2024/03/28 AB Define passive and active drug absorption.Explain how Fick’s law of diffusion relates to passive drug absorption.Calculate the percent of drug nonionized and ionized for a weak acid or weak-base drug using the Henderson–Hasselbalch equation, and explain how this may affect drug absorption.Define transcellular and paracellular drug absorption and explain using drug examples.Describe the anatomy and physiology of the GI tract and explain how stomach emptying time and GI transit time can alter the rate and extent of drug absorption.Explain the effect of food on gastrointestinal physiology and systemic drug absorption.Describe the various transporters and how they influence the pharmacokinetics of drug disposition in the GI tract.Explain the pH-partition hypothesis and how gastrointestinal pH and the pKa of a drug may influence systemic drug absorption. Describe how drug absorption may be affected by a disease that causes changes in intestinal blood flow and/or motility.List the major factors that affect drug absorption from oral and nonoral routes of drug administration.Describe various methods that may be used to study oral drug absorption from the gastrointestinal transit.