RT Book, Section
A1 Yue, Corinne Seng
A1 Ducharme, Murray P.
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117903030
T1 Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental Analysis
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117903030
RD 2024/04/20
AB Describe  the  differences  between  empirical  and  mechanistic  models.Understand  the  differences  between  different  types  of  compartmental  analyses.Describe  the  physiologic  pharmacokinetic  model  with  equations  and  underlying  assumptions.List  the  differences  in  data  analysis  between  the  physiologic  pharmacokinetic  model,  the  classical  compartmental  model,  and  the  noncompartmental  approaches.Describe  interspecies  scaling  and  its  application  in  pharmacokinetics  and  toxicokinetics.Describe  the  statistical  moment  theory  and  explain  how  it  provides  a  unique  way  to  study  time-related  changes  in  macroscopic  events.Define  mean  residence  time  (MRT)  and  how  it  can  be  calculated.Define  the  mean  transit  time  (MTT)  and  how  it  can  be  used  to  calculate  the  mean  dissolution  time  (MDT),  or  in  vivo  mean  dissolution  time,  for  a  solid  drug  product  given  orally.Using  MRT,  derive  equations  to  estimate  other  pharmacokinetic  parameters  such  as  mean  absorption  time  and  total  volume  of  distribution.