RT Book, Section
A1 Yue, Corinne Seng
A1 Ducharme, Murray P.
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117903030
T1 Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental Analysis
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117903030
RD 2020/06/02
AB Describe the differences between empirical and mechanistic models.Understand the differences between different types of compartmental analyses.Describe the physiologic pharmacokinetic model with equations and underlying assumptions.List the differences in data analysis between the physiologic pharmacokinetic model, the classical compartmental model, and the noncompartmental approaches.Describe interspecies scaling and its application in pharmacokinetics and toxicokinetics.Describe the statistical moment theory and explain how it provides a unique way to study time-related changes in macroscopic events.Define mean residence time (MRT) and how it can be calculated.Define the mean transit time (MTT) and how it can be used to calculate the mean dissolution time (MDT), or in vivo mean dissolution time, for a solid drug product given orally.Using MRT, derive equations to estimate other pharmacokinetic parameters such as mean absorption time and total volume of distribution.