RT Book, Section
A1 Moy, Beverly
A1 Goss, Paul
A1 Lee, Richard J.
A1 Smith, Matthew
A2 Brunton, Laurence L.
A2 Chabner, Bruce A.
A2 Knollmann, Björn C.
SR Print(0)
ID 1127871809
T1 Natural Products in Cancer Chemotherapy: Hormones and Related Agents
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071624428
LK accesspharmacy.mhmedical.com/content.aspx?aid=1127871809
RD 2023/02/08
AB The  growth  of  a  number  of  cancers  is  hormone  dependent  or  regulated  by  hormones.  Research  in  the  fields  of  fertility,  birth  control,  and  menopause  has  yielded  valuable  hormone  analogs  and  antagonists  for  the  treatment  of  both  breast  and  prostate  cancer.  These  molecules  interrupt  the  stimulatory  axis  created  by  systemic  pools  of  androgens  and  estrogens,  inhibit  hormone  production  or  binding  to  receptors,  and  ultimately  block  the  complex  expression  of  genes  that  promotes  tumor  growth  and  survival.  These  drugs  have  proven  effective  in  extending  survival  and  delaying  or  preventing  tumor  recurrence  in  breast  cancer  and  prostate  cancer.