RT Book, Section A1 King, Michael W. SR Print(0) ID 1122103042 T1 Hemoglobin and Myoglobin T2 Integrative Medical Biochemistry Examination and Board Review YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071786126 LK accesspharmacy.mhmedical.com/content.aspx?aid=1122103042 RD 2024/03/29 AB High-Yield TermsHeme: is formed when iron is inserted into the chemical compound protoporphyrinHemin: normal heme contains iron in the ferrous oxidation state (Fe2+), whereas hemin contains iron in the ferric oxidation state (Fe3+)Methemoglobin: the form of the hemoglobin protein that contains ferric iron (Fe3+) in the heme prosthetic groups due to oxidationHemoglobinopathy: any disease resulting from either (or both) quantitative or qualitative defects in α-globin or β-globin proteinsThalassemia: specifically refers to quantitative hemoglobinopathies due to either α-globin or β-globin protein defectsSickle cell anemia: most commonly occurring qualitative hemoglobinopathy, results from a single amino acid substitution in the adult β-globin geneCooley anemia: is thalassemia major, which is either β0− and β+-thalassemia