RT Book, Section A1 King, Michael W. SR Print(0) ID 1122103309 T1 Enzymes and Enzyme Kinetics T2 Integrative Medical Biochemistry Examination and Board Review YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071786126 LK accesspharmacy.mhmedical.com/content.aspx?aid=1122103309 RD 2021/04/16 AB High-Yield TermsSimple enzyme: binds only substrate and/or inhibitorsHoloenzyme: complex enzymes which are composed of protein plus a relatively small organic moleculeApoenzyme: the protein component of a complex enzymeCoenzymes: nonprotein components of enzymesIsozyme: member of a set of enzymes sharing similar/same substrate specificityMetalloenzyme: enzymes that require a metal in their compositionRibozymes: RNA molecules that exhibit catalytic activity in the absence of any protein componentReaction rate: described by the number of molecules of reactant(s) that are converted into product(s) in a specified time periodChemical reaction order: relates to the number of molecules in a reaction complex that can proceed to productEquilibrium constant: related to the ratio of product concentration to reactant concentration or rate constants for forward and reverse reactionsMichaelis-Menten constant (Km): relates the maximum reaction velocity to substrate concentration such that Km is the substrate concentration [S] at which a reaction has attained half the maximal velocityLineweaver-Burk plots: linear double reciprocal plots of substrate concentration versus reaction velocityAllosteric enzymes: defined as any enzyme whose activity is altered by binding small molecule regulators referred to as effectors; plots of substrate concentration versus reaction velocity are sigmoidal instead of curvilinear