RT Book, Section
A1 King, Michael W.
SR Print(0)
ID 1122103791
T1 Lipids: Fatty Acid Synthesis
T2 Integrative Medical Biochemistry Examination and Board Review
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071786126
LK accesspharmacy.mhmedical.com/content.aspx?aid=1122103791
RD 2024/04/23
AB High-Yield  TermsATP-citrate  lyase  (ACL):  cytosolic  enzyme  involved  in  the  transport  of  acetyl-CoA  from  the  mitochondria  to  the  cytosol;  a  nuclear  ACL  is  involved  in  delivery  of  acetyl-CoA  to  histone  acetyltransferases  (HAT)  involved  in  modulating  gene  expression  at  the  level  of  epigenetic  markingAcetyl-CoA  carboxylase  (ACC):  rate-limiting  and  highly  regulated  enzyme  of  de  novo  fatty  acid  synthesisFatty  acid  synthase  (FAS):  homodimeric  enzyme  that  carries  out  all  of  the  reactions  of  de  novo  fatty  acid  synthesis  generating  palmitic  acid  as  the  final  productCarbohydrate-response  element-binding  protein:  major  glucose-responsive  transcription  factor  that  is  required  for  glucose-induced  expression  of  L-PK  and  the  lipogenic  genes  ACC  and  FASSteroyl-CoA  desaturase  (SCD):  rate-limiting  enzyme  for  the  synthesis  of  monounsaturated  fatty  acids  (MUFAs),  primarily  oleate  (18:1)  and  palmitoleate  (16:1),  both  of  which  represent  the  majority  of  MUFA  present  in  membrane  phospholipids,  triglycerides,  and  cholesterol  esters