RT Book, Section A1 King, Michael W. SR Print(0) ID 1122103892 T1 Lipids: The Eicosanoids: Prostaglandins, Leukotrienes, and Thromboxanes T2 Integrative Medical Biochemistry Examination and Board Review YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071786126 LK accesspharmacy.mhmedical.com/content.aspx?aid=1122103892 RD 2024/10/13 AB High-Yield TermsEicosanoids: a family of bioactive lipids derived via the oxidation of 20-carbon omega-3 or omega-6 polyunsaturated fatty acids, such as prostaglandins, thromboxanes, and leukotrienesCyclic pathway: describes the pathway, initiated by prostaglandin G/H synthase, PGS (also called prostaglandin endoperoxide synthetase), for the synthesis of arachidonic acid-derived eicosanoids containing a cyclic moietyLinear pathway: describes the pathway, initiated through the action of lipoxygenases (LOXs), for the synthesis of arachidonic acid-derived eicosanoids with linear structureCyclooxygenase (COX): common name for prostaglandin G/H synthase which possesses both cyclooxygenase and peroxidase activities, 2 principal COX enzymes exist in humans, COX1 and COX2Peptidoleukotrienes: also called the cysteinyl leukotrienes, LTC4, LTD4, LTE4, and LTF4 constitute this group of eicosanoids because of the presence of amino acidsSlow-reacting substance of anaphylaxis (SRS-A): consists of the leukotrienes LTC4, LTD4, and LTE4, secreted by mast cells during anaphylactic reaction, induces slow contraction of smooth muscle resulting in bronchoconstriction