RT Book, Section
A1 King, Michael W.
SR Print(0)
ID 1122104110
T1 Lipids: Cholesterol Metabolism
T2 Integrative Medical Biochemistry Examination and Board Review
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071786126
LK accesspharmacy.mhmedical.com/content.aspx?aid=1122104110
RD 2024/04/18
AB High-Yield  TermsCholesterol  ester:  product  of  fatty  acid  esterification  of  the  3-OH  catalyzed  by  ACAT  or  LCATReverse  cholesterol  transport:  process  by  which  cholesterol  is  transferred  from  nonhepatic  cells  to  HDLs  and  then  transported  back  to  the  liver  via  bloodLDL:  low-density  lipoprotein,  derived  from  de  novo  VLDL  synthesized  in  the  liver,  referred  to  as  “bad  cholesterol”HDL:  lipoprotein  particle  involved  in  reverse  cholesterol  transport,  referred  to  as  “good  cholesterol”SREBP2:  sterol-regulated  element-binding  protein  2,  controls  the  expression  of  genes  involved  in  hepatic  cholesterol  biosynthesisSCAP:  SREBP  cleavage-activating  protein,  cleaves  the  transcription  factor  domain  from  ER-embedded  SREBP,  allowing  it  to  migrate  to  the  nucleusInsig:  insulin-regulated  gene,  regulates  the  activity  of  SCAPIsoprenoid:  any  compound  containing  the  5-carbon  organic  molecule  isoprene  (also  called  terpene)  with  the  formula:  CH2=C−(CH3)−CH=CH2Prenylation:  process  of  attaching  isoprenoid  intermediates  of  the  cholesterol  biosynthetic  pathway  (farnesyl  pyrophosphate  and  geranylgeranyl  pyrophosphate)  to  proteins