RT Book, Section
A1 King, Michael W.
SR Print(0)
ID 1122105485
T1 Insulin Function
T2 Integrative Medical Biochemistry Examination and Board Review
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071786126
LK accesspharmacy.mhmedical.com/content.aspx?aid=1122105485
RD 2024/04/25
AB High-Yield  TermsIncretin:  any  gut  hormone  associated  with  food  intake-stimulation  of  insulin  secretion  from  the  pancreasGlucose-stimulated  insulin  secretion,  GSIS:  process  of  glucose  uptake  and  metabolism  by  β-cells  leading  to  increased  ATP  production  which  inhibits  a  potassium-dependent  ATP  (KATP)  channel  resulting  in  depolarization  of  the  membrane  triggering  calcium  influx  and  insulin  secretory  vesicle  fusion  with  plasma  membraneABCC8/KCNJ11:  ATP-binding  cassette,  subfamily  C,  member  8  (ABCC8-encoded  protein  is  also  known  as  the  sulfonylurea  receptor,  SUR)  and  potassium  inwardly  rectifying  channel,  subfamily  J,  member  11,  protein  components  of  the  KATP  channel  of  β-cells  that  regulates  insulin  secretionTCF7L2:  transcription  factor  7-like  2,  T-cell–specific  HMG-box,  involved  in  Wnt  signal  transduction,  polymorphisms  in  this  gene  are  the  most  highly  correlated  with  potential  for  development  of  T2DInsulin  resistance,  IR:  a  phenomenon  whereby  binding  of  insulin  to  its  receptor  results  in  impaired  or  failed  propagation  of  normal  signal  transduction  events