RT Book, Section
A1 Li, Jie Jack
A1 Renslo, Adam
A2 Renslo, Adam
SR Print(0)
ID 1124842712
T1 Nucleophilic Substitution, Addition, and Elimination Reactions
T2 The Organic Chemistry of Medicinal Agents
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071794213
LK accesspharmacy.mhmedical.com/content.aspx?aid=1124842712
RD 2024/04/23
AB The  first  few  chapters  of  this  text  were  focused  on  important  properties  of  organic  molecules  and  how  these  help  determine  the  nature  of  a  drug’s  interaction  with  its  biological  target.  In  this  chapter  and  the  ones  that  follow,  we  will  discuss  certain  reactions  of  drug  molecules  and  enzymes  –  biological  macromolecules  that  break  and  form  chemical  bonds.  In  this  chapter  we  discuss  substitution,  addition,  and  elimination  reactions.  The  main  focus  is  on  substitution  reactions,  which  are  prevalent  in  physiological  and  metabolic  processes,  in  the  action  of  some  drugs,  and  in  the  chemical  synthesis  of  nearly  all  drugs.  The  topic  of  addition  reactions  is  introduced  here  and  expanded  upon  in  the  following  chapter  on  carbonyl  chemistry.