RT Book, Section
A1 Hilal-Dandan, Randa
A1 Brunton, Laurence L.
SR Print(0)
ID 1127547285
T1 Drug Invention and the Pharmaceutical Industry
T2 Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071769174
LK accesspharmacy.mhmedical.com/content.aspx?aid=1127547285
RD 2024/04/24
AB The  first  edition  of  Goodman  &  Gilman  helped  to  organize  the  field  of  pharmacology,  giving  it  intellectual  validity  and  an  academic  identity.  That  edition  began:  "The  subject  of  pharmacology  is  a  broad  one  and  embraces  the  knowledge  of  the  source,  physical  and  chemical  properties,  compounding,  physiological  actions,  absorption,  fate,  and  excretion,  and  therapeutic  uses  of  drugs.  A  drug  may  be  broadly  defined  as  any  chemical  agent  that  affects  living  protoplasm,  and  few  substances  would  escape  inclusion  by  this  definition."  This  General  Principles  section  provides  the  underpinnings  for  these  definitions  by  exploring  the  processes  of  drug  invention,  followed  by  the  basic  properties  of  the  interactions  between  the  drug  and  biological  systems:  pharmacodynamics,  pharmacokinetics  (including  drug  transport  and  metabolism),  and  pharmacogenomics.  Subsequent  sections  deal  with  the  use  of  drugs  as  therapeutic  agents  in  human  subjects.