RT Book, Section
A1 Hilal-Dandan, Randa
A1 Brunton, Laurence L.
SR Print(0)
ID 1127547903
T1 Anticholinesterase Agents
T2 Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071769174
LK accesspharmacy.mhmedical.com/content.aspx?aid=1127547903
RD 2024/04/23
AB Acetylcholinesterase  (AChE)  terminates  the  action  of  acetylcholine  (ACh)  at  the  junctions  of  the  various  cholinergic  nerve  endings  with  their  effector  organs  or  postsynaptic  sites  (seeChapter  8).  Drugs  that  inhibit  AChE  are  called  anticholinesterase  (anti-ChE)  agents.  They  cause  ACh  to  accumulate  in  the  vicinity  of  cholinergic  nerve  terminals  and  thus  are  potentially  capable  of  producing  effects  equivalent  to  excessive  stimulation  of  cholinergic  receptors  throughout  the  central  and  peripheral  nervous  systems.  The  anti-ChE  agents  have  received  extensive  application  as  toxic  agents,  in  the  form  of  agricultural  insecticides,  pesticides,  and  potential  chemical  warfare  "nerve  gases."  Nevertheless,  some  compounds  of  this  class  are  used  therapeutically  for  the  treatment  of  Alzheimer  disease.