RT Book, Section A1 Hilal-Dandan, Randa A1 Brunton, Laurence L. SR Print(0) ID 1127553471 T1 Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections T2 Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071769174 LK accesspharmacy.mhmedical.com/content.aspx?aid=1127553471 RD 2024/03/29 AB The sulfonamide drugs were the first effective chemotherapeutic agents to be employed systemically for the prevention and cure of bacterial infections in humans. The advent of penicillin and other antibiotics diminished the usefulness of the sulfonamides, but the introduction of the combination of trimethoprim and sulfamethoxazole has increased the use of sulfonamides for the prophylaxis and treatment of specific microbial infections. Sulfonamides are derivatives of para-aminobenzenesulfonamide (sulfanilamide; Figure 52-1) and are congeners of para-aminobenzoic acid. Most of them are relatively insoluble in water, but their sodium salts are readily soluble.