RT Book, Section
A1 Hilal-Dandan, Randa
A1 Brunton, Laurence L.
SR Print(0)
ID 1127553701
T1 Aminoglycosides
T2 Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071769174
LK accesspharmacy.mhmedical.com/content.aspx?aid=1127553701
RD 2024/04/20
AB Aminoglycosides  (gentamicin,  tobramycin,  amikacin,  netilmicin,  kanamycin,  streptomycin,  paromomycin,  and  neomycin)  are  used  primarily  to  treat  infections  caused  by  aerobic  gram-negative  bacteria.  Streptomycin  is  an  important  agent  for  the  treatment  of  tuberculosis,  and  paromomycin  is  used  orally  for  intestinal  amebiasis  and  in  the  management  of  hepatic  coma.  Aminoglycosides  are  bactericidal  inhibitors  of  protein  synthesis.  Mutations  affecting  proteins  in  the  bacterial  ribosome  can  confer  marked  resistance  to  their  action.  Most  commonly  resistance  is  due  to  acquisition  of  plasmids  or  transposon-encoding  genes  for  aminoglycoside-metabolizing  enzymes  or  from  impaired  transport  of  drug  into  the  cell.  Thus,  there  can  be  cross-resistance  between  members  of  the  class.