RT Book, Section
A1 Kang-Birken, S. Lena
A2 DiPiro, Joseph T.
A2 Talbert, Robert L.
A2 Yee, Gary C.
A2 Matzke, Gary R.
A2 Wells, Barbara G.
A2 Posey, L. Michael
SR Print(0)
ID 1148444821
T1 Sepsis and Septic Shock
T2 Pharmacotherapy: A Pathophysiologic Approach, 10e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259587481
LK accesspharmacy.mhmedical.com/content.aspx?aid=1148444821
RD 2024/10/15
AB Content  UpdateOctober  31,  2017Lower  Mortality  with  Rapid  Completion  of  3-hour  Sepsis  Bundle:  Inappropriate  antimicrobial  selection  and  delays  in  initiating  therapy  are  associated  with  increased  mortality  in  patients  with  sepsis.  Sepsis  "bundles"  and  practice  guidelines  are  associated  with  reduced  mortality  in  sepsis  patients.  A  recent  publication  involving  more  than  40,000  patients  with  sepsis  and  septic  shock  at  149  New  York  hospitals  reported  on  a  sepsis  protocol  initiated  within  6  hours  of  arrival  that  included  a  3-hour  bundle  of  care  (blood  cultures,  broad-spectrum  antibiotics,  and  lactate  measurement).  Risk-adjusted  in-hospital  mortality  was  higher  in  patients  when  the  sepsis  bundle  was  completed  in  12  hours  vs.  the  goal  of  within  3  hours.  Longer  time  to  administration  of  antibiotics  was  also  associated  with  higher  in-hospital  mortality.