RT Book, Section
A1 Veverka, Angie
A1 Odle, Brian L.
A1 Kyle, Jeffrey A.
A2 DiPiro, Joseph T.
A2 Talbert, Robert L.
A2 Yee, Gary C.
A2 Matzke, Gary R.
A2 Wells, Barbara G.
A2 Posey, L. Michael
SR Print(0)
ID 1160945000
T1 Infective Endocarditis
T2 Pharmacotherapy: A Pathophysiologic Approach, 10e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259587481
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160945000
RD 2024/04/24
AB Content  UpdateJan.  30,  2019Partial  Oral  Treatment  of  Bacterial  Infective  Endocarditis:  Effectiveness  of  oral  treatment  for  infective  endocarditis  (IE)  has  been  investigated  since  the  1940s.  Retrospective  observational  studies  and  few  small  randomized  trials  have  suggested  promising  results  with  certain  highly  bioavailable  oral  regimens.  “The  Partial  Oral  versus  Intravenous  Antibiotic  Treatment  of  Endocarditis”  or  “POET”  trial  randomized  400  adult  patients  with  left-sided  IE  to  either  continued  IV  treatment  or  conversion  to  oral  therapy.  Difference  in  the  composite  efficacy  end  point  between  groups  met  the  study’s  non-inferiority  criteria  (3.1%;  95%  confidence  interval,  -3.4  to  9.6;  P  =  0.40).  The  average  patient  in  the  POET  trial  may  look  quite  different  from  the  typical  IE  patient  in  many  US  hospitals.  Pathogen,  oral  antibiotic  choice,  and  individual  patient  characteristics  should  be  considered  when  assessing  potential  candidates  for  partial  oral  therapy.