RT Book, Section
A1 Sanoski, Cynthia A.
A1 Bauman, Jerry L.
A2 DiPiro, Joseph T.
A2 Talbert, Robert L.
A2 Yee, Gary C.
A2 Matzke, Gary R.
A2 Wells, Barbara G.
A2 Posey, L. Michael
SR Print(0)
ID 1153483491
T1 The Arrhythmias
T2 Pharmacotherapy: A Pathophysiologic Approach, 10e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259587481
LK accesspharmacy.mhmedical.com/content.aspx?aid=1153483491
RD 2024/04/24
AB Content  UpdateMay  16,  2018Anticoagulation  in  Older  Patients  with  Atrial  Fibrillation  and  Chronic  Kidney  Disease:  A  retrospective  propensity-matched  cohort  study  in  the  UK  evaluated  the  safety  and  effectiveness  of  anticoagulation  for  thromboprophylaxis  in  older  patients  with  chronic  kidney  disease  (CKD)  after  being  diagnosed  with  atrial  fibrillation  (AF).  Compared  to  matched  controls,  patients  receiving  anticoagulation  were  more  likely  to  experience  ischemic  stroke  and  cerebral  or  GI  hemorrhage  but  had  lower  all-cause  mortality.  Although  anticoagulants  may  improve  all-cause  mortality  in  these  patients,  additional  trials  are  needed  to  determine  the  effect  of  anticoagulation  on  stroke  risk.  Anticoagulant  use  should  be  based  on  assessment  of  individual  bleeding  and  thromboembolic  risks  and  benefits,  along  with  consideration  of  patient  preferences.