RT Book, Section
A1 Chessman, Katherine H.
A1 Haney, Jason
A2 DiPiro, Joseph T.
A2 Talbert, Robert L.
A2 Yee, Gary C.
A2 Matzke, Gary R.
A2 Wells, Barbara G.
A2 Posey, L. Michael
SR Print(0)
ID 1161376537
T1 Disorders of Sodium and Water Homeostasis
T2 Pharmacotherapy: A Pathophysiologic Approach, 10e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259587481
LK accesspharmacy.mhmedical.com/content.aspx?aid=1161376537
RD 2024/04/18
AB Content  UpdateFebruary  1,  2019Normal  saline  versus  balanced  fluids  for  volume  resuscitation:  A  long-standing  controversy  has  been  the  relative  benefits  of  0.9%  normal  saline  versus  balanced  intravenous  crystalloids  (lactated  Ringer's  and  Plasma-Lyte  A).  Accumulating  observational  data  increasingly  suggests  that  the  hyperchloremic  metabolic  acidosis  associated  with  the  administration  of  large  volumes  of  saline  leads  to  increased  rates  of  acute  kidney  injury  and  need  for  dialysis.  Two  recent,  large,  randomized  trials  (SMART  and  SALT-ED)  have  attempted  to  answer  this  question  in  both  critically  ill  and  in  non-critically  ill  patient  populations.  Although  the  question  is  not  yet  definitively  resolved,  these  studies  further  suggest  that  major  adverse  kidney  events  are  more  frequently  seen  in  patients  resuscitated  with  normal  saline.