RT Book, Section A1 Rybak, Michael J. A1 Aeschlimann, Jeffrey R. A1 LaPlante, Kerry L. A2 DiPiro, Joseph T. A2 Talbert, Robert L. A2 Yee, Gary C. A2 Matzke, Gary R. A2 Wells, Barbara G. A2 Posey, L. Michael SR Print(0) ID 1145264766 T1 Laboratory Tests to Direct Antimicrobial Pharmacotherapy T2 Pharmacotherapy: A Pathophysiologic Approach, 10e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259587481 LK accesspharmacy.mhmedical.com/content.aspx?aid=1145264766 RD 2024/10/05 AB Content UpdateJuly 12, 2017Using Cystatin C to Guide Vancomycin Dosing: Cystatin C is a renal biomarker that has been proposed to be used as an alternative to or in conjunction with creatinine for estimating glomerular filtration rate (GFR). Two recent studies employed a practical approach to development and implementation of a cystatin C-inclusive vancomycin dosing nomogram in clinical practice. The authors developed a dosing nomogram that used CKD-EPIcreatinine-cystatinC based estimated GFR (eGFRcr-cysC) as well as the target vancomycin trough level and patient weight. The authors then conducted a QI project to evaluate the routine use of this nomogram in critically-ill patients. Use of the CKD-EPIcreatinine-cystatinC equation to estimate GFR for vancomycin dosing was shown to be feasible and was associated with a clinically and statistically significant increase in target vancomycin trough achievement. Additional prospective research is warranted.