RT Book, Section A1 Stringer, Janet L. SR Print(0) ID 1142821351 T1 Local Anesthetics T2 Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 5e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259861079 LK accesspharmacy.mhmedical.com/content.aspx?aid=1142821351 RD 2024/03/28 AB These drugs are applied locally and block nerve conduction. Nerve fibers are not affected equally. Loss of sympathetic function occurs first, followed by loss of pinprick sensation and temperature, and, finally, motor function. The effect of local anesthetics is reversible: their use is followed by complete recovery of nerve function with no evidence of structural damage.