RT Book, Section
A1 Kennelly, Peter J.
A1 Rodwell, Victor W.
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160189329
T1 Enzymes: Regulation of Activities
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160189329
RD 2024/04/25
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Explain  the  concept  of  whole-body  homeostasis.Discuss  why  the  cellular  concentrations  of  substrates  for  most  enzymes  tend  to  be  close  to  Km.List  multiple  mechanisms  by  which  active  control  of  metabolite  flux  is  achieved.State  the  advantages  of  synthesizing  certain  enzymes  as  proenzymes.Describe  typical  structural  changes  that  accompany  conversion  of  a  proenzyme  to  its  active  form.Indicate  two  general  ways  in  which  an  allosteric  effector  can  influence  catalytic  activity.Outline  the  roles  of  protein  kinases,  protein  phosphatases,  and  of  regulatory  and  hormonal  and  second  messengers  in  regulating  metabolic  processes.Explain  how  the  substrate  requirements  of  lysine  acetyltransferases  and  sirtuins  can  trigger  shifts  in  the  degree  of  lysine  acetylation  of  metabolic  enzymes.Describe  two  ways  by  which  regulatory  networks  can  be  constructed  in  cells.