RT Book, Section
A1 Kennelly, Peter J.
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160189412
T1 The Biochemical Roles of Transition Metals
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160189412
RD 2024/04/23
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Explain  why  essential  transition  metals  are  often  referred  to  as  micronutrients.Understand  the  importance  of  multivalency  to  the  ability  of  transition  metals  to  participate  in  electron  transport  and  oxidation–reduction  reactions.Understand  how  Lewis  and  Bronsted-Lowry  acids  differ.Define  the  term  complexation  as  it  refers  to  metal  ions.Provide  a  rationale  for  why  zinc  is  a  common  prosthetic  group  in  enzymes  that  catalyze  hydrolytic  reactions.List  four  benefits  obtained  by  incorporating  transition  metals  into  organometallic  complexes  in  vivo.Cite  examples  of  the  ability  of  a  given  transition  metal  to  function  as  an  electron  carrier  in  one  protein,  an  oxygen  carrier  in  another,  and  a  redox  catalyst  in  yet  another.Explain  how  the  possession  of  multiple  metal  ions  enables  the  metalloenzymes  cytochrome  oxidase  and  nitrogenase  to  catalyze  the  reduction  of  molecular  oxygen  and  nitrogen,  respectively.Describe  two  mechanisms  by  which  excess  levels  of  transition  metals  can  be  harmful  to  living  organisms.Provide  an  operational  definition  of  the  term  “heavy  metal,”  and  list  three  strategies  for  treating  acute  heavy  metal  poisoning.Describe  the  processes  by  which  Fe,  Co,  Cu,  and  Mo  are  absorbed  in  the  human  gastrointestinal  tract.Describe  the  metabolic  role  of  sulfite  oxidase  and  the  pathology  of  sulfite  oxidase  deficiency.Describe  the  function  of  zinc  finger  motifs  and  provide  an  example  of  their  role  in  metal  ion  metabolism.